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. 2020 Sep 18;21(10):e49585. doi: 10.15252/embr.201949585

Figure 1. Enzymatic degradation of RNA causes protein aggregation.

Figure 1

  • A
    Diagram showing the experimental design.
  • B
    SDS–PAGE analysis of soluble (Supernatant) and insoluble proteins (Pellet) from human neurons after treatment for one hour with a mixture of RNase A and RNase T1 (A/T1), or vehicle (Ve‐).
  • C
    Protein aggregation (Pellet) after incubation with different ribonucleases or DNase I in the presence of either EDTA or Mg2+. Ribonucleases used were RNase A (A), RNase T1 (T1), a mixture of RNase A and RNase T1 (A/T1), RNase 1f (1f) and RNase V1 (V1).