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. 2020 Aug 12;21(10):e49689. doi: 10.15252/embr.201949689

Figure EV3. Forced expression of circLMP2A promoted tumour growth, angiogenesis and metastasis in vivo .

Figure EV3

  • A, B
    Subcutaneously established tumour xenografts in NOD/SCID mice. Tumour volume (A) and tumour weight (B) of the xenografts were significantly increased by over‐expression of circLMP2A.
  • C
    WB analysis of the expression of TRIM59 and p53 in tumour xenografts.
  • D
    The expression of TRIM59, p53 and ERG was measured using IHC in tumour xenografts.
  • E, F
    Representative images of bioluminescence (E) and lung metastases (F) are presented to measure the metastatic colonies.
Data information: Results are presented as the mean ± SD, six mice per group, biological replicates, scale bars = 50 μm, *P < 0.05; **P < 0.01; ***P < 0.001, Student's t‐test. Source data are available online for this figure.