Figure 6. Transcriptome analysis reveals increased expression of inflammation and lysosome genes in Tmem106b ^−/− Grn ^−/− mice.

• A, B
  Heatmap illustrating gene expression changes in WT, Tmem106b ^−/− , Grn ^−/− , and Tmem106b ^−/− Grn ^−/− cortex (A) and spinal cord (B) samples isolated from 2.7‐month‐old mice. n = 3. Genes with FDR P ≤ 0.05, LogFC ≥ 0.5 or ≤ 0.5 between WT and Tmem106b ^−/− Grn ^−/− groups are plotted based on hierarchical clustering analysis.
• C
  Heatmap illustrating gene expression changes in the inflammation and lysosome pathways in WT, Tmem106b ^−/−, Grn ^−/−, and Tmem106b ^−/− Grn ^−/− spinal cord samples.

Data information: Inflammation genes are highlighted in magenta, and lysosomal genes are highlighted in blue.