Demographic and clinical characteristics |
Age, years |
57 (44–69) |
72 (66–79) |
51 (40–63) |
<0.0001 |
Sex |
|
|
|
0.004 |
Male |
113 (48%) |
42 (63%) |
71 (42%) |
.. |
Female |
123 (52%) |
25 (37%) |
98 (58%) |
.. |
Comorbidities |
93 (39%) |
48 (72%) |
45(27%) |
<0.0001 |
Hypertension |
60 (25%) |
35 (52%) |
25 (15%) |
<0.0001 |
Diabetes |
28 (12%) |
15 (22%) |
13 (8%) |
0.002 |
Cardiovascular disease |
27 (11%) |
18 (27%) |
9 (5%) |
<0.0001 |
Cerebrovascular disease |
8 (3%) |
5 (7%) |
3 (2%) |
0.075 |
Respiratory system disease |
12 (5%) |
10 (15%) |
2 (1%) |
<0.0001 |
Malignancy |
11 (5%) |
6 (9%) |
5 (3%) |
0.10 |
Chronic liver disease |
5 (2%) |
1 (1%) |
4 (2%) |
1.0 |
Signs and symptoms at admission |
Fever |
194 (82%) |
57 (85%) |
137 (81%) |
0.47 |
Cough |
133 (56%) |
38 (57%) |
95 (56%) |
0.94 |
Fatigue |
81 (34%) |
27 (40%) |
54 (32%) |
0.22 |
Expectoration |
60 (25%) |
22 (33%) |
38 (22%) |
0.10 |
Shortness of breath |
60 (25%) |
27 (40%) |
33 (20%) |
0.001 |
Chest tightness |
51 (22%) |
22 (33%) |
29 (17%) |
0.008 |
Dyspnoea |
35 (15%) |
19 (28%) |
16 (9%) |
<0.0001 |
Diarrhea |
31 (13%) |
9 (13%) |
22 (13%) |
0.93 |
Dizziness or headache |
22 (9%) |
5 (7%) |
17 (10%) |
0.54 |
Sore throat |
18 (8%) |
2 (3%) |
16 (9%) |
0.091 |
Myalgia |
17 (7%) |
2 (3%) |
15 (9%) |
0.19 |
Nausea or vomiting |
14 (6%) |
4(6%) |
10 (6%) |
1.0 |
Disturbance of consciousness |
7 (3%) |
6 (9%) |
1 (0.6%) |
0.003 |
Laboratory findings |
White blood cell count, × 109/L |
5.5 (4.2–7.7) |
8.2 (5.5–12.3) |
5.0 (3.9–6.5) |
<0.0001 |
Neutrophil count, × 109/L |
3.8 (2.5–6.1) |
7.3 (4.5–11.3) |
3.0 (2.3–4.4) |
<0.0001 |
Lymphocyte count, × 109/L |
1.1 (0.8–1.5) |
0.6 (0.4–0.9) |
1.2 (1.0–1.6) |
<0.0001 |
Monocyte count, × 109/L |
0.4 (0.3–0.6) |
0.4 (0.2–0.5) |
0.5 (0.3–0.6) |
<0.0001 |
Eosinophil count, × 109/L |
0.01 (0–0.06) |
0 (0–0) |
0.03 (0–0.09) |
<0.0001 |
Basophil count, × 109/L |
0.01 (0.01–0.03) |
0.01 (0.01–0.02) |
0.02 (0.01–0.03) |
0.021 |
Procalcitonin, ng/mL |
0.05 (0.03–0.13) |
0.23 (0.10–0.59) |
0.04 (0.03–0.06) |
<0.0001 |
C-reactive protein, mg/L |
29 (5–73) |
92 (59–167) |
10 (5–35) |
<0.0001 |
Prothrombin time, s |
12.0 (11.4–12.7) |
12.8 (12.1–13.8) |
11.9 (11.2–12.3) |
<0.0001 |
Activated partial thromboplastin time, s |
27.8 (25.9–30.5) |
28.8 (27.0–32.5) |
27.5 (25.1–29.6) |
0.001 |
D-dimer, mg/L |
0.73 (0.37–2.92) |
4.67 (1.15–17.16) |
0.47 (0.29–1.09) |
<0.0001 |
Alanine aminotransferase, U/L |
25 (17–43) |
25 (20–46) |
25 (16–43) |
0.256 |
Aspartate aminotransferase, U/L |
28 (20–44) |
45 (28–63) |
24 (19–36) |
<0.0001 |
Total bilirubin, mmol/L |
10.6 (8.0–15.5) |
14.3 (9.8–20.2) |
9.8 (7.5–14.2) |
<0.0001 |