Table 1.

Population, Intervention, Comparison, Outcome (PICO) Research Strategy for systematic review

PICO	Description
Population	Adults and children with diagnosed CF.
Intervention	Articles describing PROMs used to assess health-related quality of life in CF.
	Articles describing both generic and disease-specific measures will be included.
Comparison	Studies without a comparator will be considered for inclusion.
Outcome	Primary outcome measure is: Identifying PROMs in CF population.
		Secondary outcome measures are: Contexts in which PROMs have previously been used. Administration methods of PROMs. Assessed or stated validity and reliability of PROMs. Acceptability of PROMs for patient population.

CF, cystic fibrosis; PROMs, patient-reported outcome measures.