Table 4.
Outcome measures to be collected
| Outcome measures | Data collection instrument | Time points of assessment |
| Primary outcome | ||
| Sit-to-stand function | 30 s chair stand test | B, S, 3 and 12 months |
| Secondary outcomes | ||
| Ambulatory capacity | Timed up and go | B, S, 3 and 12 months |
| Gait speed | 4x10 m walk test | B, S, 3 and 12 months |
| 1RM leg press strength | Leg press machine | B, S, 3 and 12 months |
| 1RM knee extension strength | Knee extension machine | B, S, 3 and 12 months |
| Isometric knee extensor muscle strength | Handheld Dynamometer | B, S, 3 and 12 months |
| Isometric knee flexion muscle strength | Handheld Dynamometer | B, S, 3 and 12 months |
| Myofiber morphology | Muscle Biopsies | B, S, 3 months |
| Myogenic stem cell content | Muscle Biopsies | B, S, 3 months |
| Pain | KOOS | B, S, 6 weeks, 3 and 12 months |
| Symptoms | KOOS | B, S, 6 weeks, 3 and 12 months |
| Activities of daily living | KOOS | B, S, 6 weeks, 3 and 12 months |
| Sports and recreation | KOOS | B, S, 6 weeks, 3 and 12 months |
| Quality of life | KOOS | B, S, 6 weeks, 3 and 12 months |
| Socioeconomic costs | EQ-5D | B, S, 6 weeks, 3 and 12 months |
| Adverse events | Questionnaire and medical records | 3 months |
| Exercise compliance and progression | Physiotherapist records | BFRE |
| Pain during visits | NRS for pain | B, BFRE, S, 3 and 12 months |
| Declining to be operated | Questionnaire | 3 months |
| Postoperative supervised physiotherapy | Questionnaire | 6 weeks, 3 and 12 months |
| Knee joint range of motion | Goniometer | B, S, 3 and 12 months |
| Patient characteristics and related | Questionnaire | B |
| Measurements | Questionnaire | B |
| Gender | Tape measure | B |
| Age | Electronic body mass scale | B |
| Height | Questionnaire | B |
| Body mass | Questionnaire | B |
| Civil status | Questionnaire | B |
| Educational level | Questionnaire | B |
| Employment status | Questionnaire | B |
| Substance use (alcohol, smoking) | Questionnaire | B |
| Duration of knee symptoms | Questionnaire | B |
| Pain medication during the last week | Questionnaire | B |
| Comorbidities | Questionnaire | B |
B, baseline; BFRE, low-load blood flow restricted exercise; D, during surgery; EQ-5D, EuroQol Group 5-dimension; KOOS, knee disability and osteoarthritis outcome score; 12 months, 12 months after TKR; 3 months, 3 months after TKR; NRS, Numeric Rating Scale; RM, repetition maximum; S, 0–2 days before surgery.