Table 1.
Clinicopathological Characteristics of 387 High-Risk NMIBC Patients Who Received Intravesical Instillation of BCG After TURBT
| Characteristics | Patients, n (%) |
|---|---|
| Sex | |
| Male | 277 (71.58) |
| Female | 110 (28.42) |
| Age | |
| Mean±SD | 69.49±10.84 |
| Median (range) | 71 (34–89) |
| BMI | |
| Mean±SD | 24.07±3.35 |
| Median (range) | 23.58 (17.36–36.86) |
| Smoking status | |
| Never smoker | 229 (59.17) |
| Current or ex-smoker | 158 (40.83) |
| Tumour number | |
| 1 | 173 (44.70) |
| 2~7 | 143 (36.95) |
| ≥8 | 71 (18.35) |
| Recurrence | |
| None | 180 (46.51) |
| Yes | 207 (53.49) |
| Tumour size | |
| <3cm | 303 (78.29) |
| ≥3cm | 84 (21.71) |
| Tumour grade | |
| LG | 124 (32.04) |
| HG | 263 (67.96) |
| T stage | |
| Ta | 107 (27.65) |
| Tis | 20 (5.17) |
| T1 | 260 (67.18) |
| Concomitant CIS | |
| None | 363 (93.80) |
| Yes | 24 (6.20) |
| LVI | |
| None | 356 (91.99) |
| Yes | 31 (8.01) |
| Blood cell counts, mean (SD) | |
| NEUT (×109/L) | 3.89 (1.46) |
| PLT (×109/L) | 214.18 (46.81) |
| LYMP (×109/L) | 1.94 (0.61) |
| ALB (g/L) | 41.93 (9.59) |
| Nutrition-inflammation-based parameters, mean (SD) | |
| PNI | 51.64 (11.67) |
| SII | 447.46 (139.39) |
| Oncological outcomes | |
| Radical cystectomy | 42(10.85) |
| Upper urinary tract recurrence | 13(3.36) |
| Bladder recurrence | 194(50.12) |
| Progression | 82(21.19) |
| 5-year cancer specific mortality | 43/365 (11.78) |
| 5-year overall mortality | 65/387 (16.80) |
| 5-year cancer specific mortality of highest-risk NMIBC | 35/83 (42.17) |
| 5-year overall mortality of highest-risk NMIBC | 42/90 (46.67) |
| Follow-up duration, months | |
| Median (range) | 108 (5–191) |
Abbreviations: NMIBC, non-muscle-invasive bladder cancer; BCG, Bacillus Calmette-Guerin; TURBT, transurethral resection of bladder tumour; BMI, body mass Index; LG, low grade; HG, high grade; CIS, carcinoma in situ; LVI, lymphovascular invasion; NEUT, neutrophil count; PLT, platelet count; LYMP, lymphocyte count; ALB, albumin; PNI, prognostic nutritional index; SII, systemic immune-inflammation index; SD, standard deviation.