Table 3.
Univariate and Multivariate Cox Regression Analyses for Overall Survival (OS) in High-Risk NMIBC Patients Who Received Intravesical Instillation of BCG After TURBT
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Sex | 0.966 | |||
| Male | 1(reference) | |||
| Female | 1.009(0.652–1.563) | |||
| Age (years) | <0.001 | 0.007 | ||
| <63.5 | 1(reference) | 1(reference) | ||
| ≥63.5 | 2.887(1.657–5.031) | 2.221(1.246–3.959) | ||
| BMI | 0.001 | 0.021 | ||
| <22.31 | 1(reference) | 1(reference) | ||
| ≥22.31 | 0.541(0.407–0.813) | 0.632(0.381–1.047) | ||
| Smoking status | 0.764 | |||
| Never smoker | 1(reference) | |||
| Current or ex-smoker | 0.937(0.612–1.434) | |||
| Tumour number | <0.001 | <0.001 | ||
| 1 | 1(reference) | 1(reference) | ||
| 2~7 | 2.148(1.151–4.006) | 1.752(0.933–3.289) | ||
| ≥8 | 10.959(6.201–19.368) | 7.518(4.108–13.761) | ||
| Recurrence | <0.001 | 0.007 | ||
| None | 1(reference) | 1(reference) | ||
| Yes | 2.911(1.810–4.681) | 2.007(1.213–3.321) | ||
| Tumour size | <0.001 | 0.718 | ||
| ≤3cm | 1(reference) | 1(reference) | ||
| >3cm | 2.620(1.704–4.031) | 1.104(0.645–1.890) | ||
| Tumour grade | <0.001 | <0.001 | ||
| LG | 1(reference) | 1(reference) | ||
| HG | 3.527(1.919–6.481) | 3.430(1.847–6.71) | ||
| T stage | 0.009 | 0.001 | ||
| Ta | 1(reference) | 1(reference) | ||
| Tis | 3.547(1.567–8.030) | 5.774(2.379–14.016) | ||
| T1 | 1.778(1.028–3.075) | 1.957(1.081–3.544) | ||
| Concomitant CIS | <0.001 | 0.032 | ||
| None | 1(reference) | 1(reference) | ||
| Yes | 3.827(2.343–6.250) | 1.843(1.055–3.218) | ||
| LVI | 0.001 | 0.170 | ||
| None | 1(reference) | 1(reference) | ||
| Yes | 3.843(1.770–8.343) | 1.159(0.766–3.311) | ||
| PNI | <0.001 | 0.017 | ||
| <50.17 | 1(reference) | 1(reference) | ||
| ≥50.17 | 0.412(0.272–0.626) | 0.602(0.433–0.894) | ||
| SII | <0.001 | 0.007 | ||
| <467.76 | 1(reference) | 1(reference) | ||
| ≥467.76 | 2.111(1.391–3.202) | 2.104(1.231–3.597) | ||
Note: Bold values indicate statistical significance, p<0.05.
Abbreviations: NMIBC, non-muscle-invasive bladder cancer; BCG, Bacillus Calmette-Guerin; TURBT, transurethral resection of bladder tumour; BMI, body mass Index; LG, low grade; HG, high grade; CIS, carcinoma in situ; LVI, lymphovascular invasion; PNI, prognostic nutritional index; SII, systemic immune-inflammation index.