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. 2020 Oct 1;12:9405–9415. doi: 10.2147/CMAR.S260129

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© 2020 Wang et al.

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Curcumin repressed EMT in CRC cells. (A) qPCR analysis of indicated EMT-inducing transcriptional factors in SW620 cells 48 hours after treated with either DMSO or curcumin. (B) qPCR analysis of mesenchymal marker Vimentin and epithelial marker CDH1 in SW620 cells after treated with either DMSO or curcumin. (C) Western blot analysis of indicated proteins in SW620 cells 72 hours after treatment. (D) Wound-healing assay of SW620 cells treated as indicated. (E, F) Migration (E), or invasion (F) assay performed in SW620 cells. Cells were stained with crystal violet. (G) SW620 cells were treated as indicated and subsequently injected into the tail vein of SCID mice. Left: Representative examples of the hematoxylin and eosin staining of the resected lungs are shown. Right: Quantification of metastatic tumor nodules in the lung per mouse 6 weeks after tail-vein injection. In panels A, B, D, E, F and G, results were expressed as mean ± SD. * < 0.05; *** < 0.001.

Abbreviations: CRC, colorectal cancer; DMSO, Dimethyl sulfoxide; EMT, epithelial–mesenchymal transition; qPCR, quantitative polymerase chain reaction; SCID, severe combined immune deficient.