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. 2020 Oct 5;30(23):127599. doi: 10.1016/j.bmcl.2020.127599

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Scheme 1 — Synthesis of 5′-hydroxy nucleosides (adenine and 7-deazaadenine). Reagents and Conditions: (i) R¹NH₂, DIPEA, 2-propanol, 70 ˚C (for X = N) or 140 ˚C, µwave (for X = CH); (ii) NaSMe, DMF, 90 ˚C; (iii) 10%TFA, MeOH, 70 ˚C.