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. 2020 Oct 5;30(23):127599. doi: 10.1016/j.bmcl.2020.127599

Scheme 2.

Scheme 2

Synthesis of 5′–non-hydroxy nucleosides. Reagents and Conditions: (i) TBAF, THF, rt; (ii) SOCl2, pyridine, CH3CN, −5 ˚C to rt; (iii) MsCl, pyridine, rt; (iv) 10% TFA, MeOH, 70 ˚C; (v) TBAF, THF, 70 ˚C; (vi) NaN3, DMF, 60 ˚C; (vii) NaSMe, DMF, 0 ˚C; (viii) PMe3, THF.