. 2020 Oct 5;30(23):127599. doi: 10.1016/j.bmcl.2020.127599

Table 2.

Evaluation of the inhibition by selected nucleosides of three other members of the Picornaviridae family of enteroviruses. Enviroxime is shown as a reference inhibitor. EC₅₀ (or EC₉₀, when indicated) is shown.

Compound	Visual (µM)			Neutral red (µM)
Compound	EC_{50, 90}	CC₅₀	SI₅₀	EC₅₀	CC₅₀	SI₅₀
Coxsackie virus B3 (HA 201,933 strain, Vero76 cells)
Enviroxime	<0.01	>10	>1000	<0.01	4.5	>450
17	16	>50	>3.1	16	>50	>3.1
Enterovirus 68 (US/KY/14–18953 strain, RD cells)
Enviroxime	0.032	4.2	130	0.032	1.5	47
17	32	>100	>3.1	32	>100	>3.1
31	15 (EC₉₀)	41	2.7	9.3	41	4.4
48	7.7 (EC₉₀)	42	5.4	16	42	2.6
Poliovirus 1 (Mahoney strain, Vero76 cells)
Enviroxime	0.015	>10	>670	<0.01	4.9	>490
17	28	>100	>3.6	27	>100	>3.7