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. 2020 Sep 16;40(38):7241–7254. doi: 10.1523/JNEUROSCI.0444-20.2020

Figure 2.

Figure 2.

Detection of dopamine using the carbon fiber microsensors in vitro and in vivo. A, Carbon fiber microsensor used for the in vitro and in vivo experiments. It consists of carbon fibers encased in a fused silica tube (blue bracket) and a gold pin (red bracket) connected with an adhesive, which is electrically conductive, and a dental resin (black bracket). B, Background-subtracted cyclic voltammograms of five different concentrations of dopamine tested in vitro using the microsensors. C, Dopamine concentration/current response curve obtained from in vitro calibrations (N = 8). D, Background-subtracted cyclic voltammograms of five different pH increase tested in vitro. (E) pH change/current response curve obtained from in vitro calibrations (N = 10). F, Color plot of dopamine release and pH shift elicited by in vivo stimulation of the MFB (60 Hz, 180 pulses at 120 µA; black bar). G, Representative dopamine and pH training sets obtained from MFB stimulations and used for principal component regression (PCR). H, PCR-extracted dopamine concentration change (top) and pH shift (bottom) from F MFB stimulation. Error bars represent the SEM.