Table 3. A selection of GO Biological Process and Reactome Pathways enriched in APhs and/or IPhs.
For each Process or Pathway listed, the number of genes belonging to the Term and the false discovery rate (FDR) probability are reported. The colours used in Fig 6 are used to highlight the specific GO terms and are reported in the last column.
| Term name | Description | APhs_# genes | APhs_FDR | IPhs_# genes | IPhs_FDR | Color in Fig 3 |
|---|---|---|---|---|---|---|
| GO.0030036 | actin cytoskeleton organization | 36 | 1,61E-14 | 30 | 1,46E-14 | |
| GO.0032956 | regulation of actin cytoskeleton organization | 25 | 5,65E-10 | 18 | 7,57E-08 | |
| GO.0038096 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 10 | 4,43E-05 | - | - | lilac |
| GO.0007166 | cell surface receptor signaling pathway | 75 | 4,84E-10 | 57 | 7,66E-10 | |
| GO.0009611 | cellular component organization or biogenesis | 156 | 3,64E-18 | - | - | |
| GO.0019886 | cytokine production | 10 | 5,50E-04 | - | - | |
| GO.0019221 | cytokine-mediated signaling pathway | 27 | 4,34E-05 | 26 | 1,21E-07 | |
| GO.0007163 | establishment or maintenance of cell polarity | 11 | 4,80E-04 | 13 | 5,47E-07 | |
| GO.0006909 | Fc-gamma receptor signaling pathway involved in phagocytosis | 9 | 3,91E-05 | - | - | |
| HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 8 | 5,07E-07 | bright green | ||
| GO.0002252 | immune effector process | 81 | 9,45E-35 | 56 | 1,10E-24 | yellow |
| GO.0007229 | integrin-mediated signaling pathway | 14 | 5,42E-09 | 10 | 7,16E-07 | brown |
| GO.0051702 | interaction with symbiont | 9 | 4,68E-05 | 12 | 2,11E-09 | |
| GO.0060333 | interferon-gamma-mediated signaling pathway | - | - | 6 | 9,10E-04 | light green |
| GO.0035722 | interleukin-12-mediated signaling pathway | 6 | 9,20E-04 | 8 | 1,36E-06 | |
| HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9 | 4,50E-04 | - | - | fuchsia |
| GO.0044419 | interspecies interaction between organisms | 46 | 4,37E-14 | 39 | 2,97E-15 | blue |
| GO.0002443 | leukocyte mediated immunity | 71 | 2,47E-36 | 47 | 7,12E-24 | pink |
| GO.0051851 | modification by host of symbiont morphology or physiology | 7 | 1,10E-03 | 11 | 1,57E-08 | |
| GO.0010951 | negative regulation of endopeptidase activity | 22 | 2,26E-09 | 24 | 2,29E-14 | |
| GO.0051172 | negative regulation of nitrogen compound metabolic process | 58 | 5,90E-04 | 52 | 5,51E-07 | |
| GO.0002446 | neutrophil mediated immunity | 63 | 1,28E-34 | 43 | 5,50E-24 | |
| GO.0071840 | phagocytosis | 29 | 1,25E-17 | 17 | 7,66E-10 | |
| GO.0045089 | positive regulation of innate immune response | 19 | 6,60E-07 | - | - | purple |
| GO.0051092 | positive regulation of NF-kappaB transcription factor activity | - | - | 9 | 2,30E-04 | light green |
| GO.0002224 | regulation of ERK1 and ERK2 cascade | 14 | 8,00E-04 | - | - | orange |
| GO.0032680 | regulation of TNF production | - | - | 9 | 5,71E-05 | light green |
| GO.0009605 | response to external stimulus | 62 | 6,39E-08 | 54 | 5,10E-11 | |
| GO.0042060 | response to wounding | 47 | 4,33E-19 | 42 | 9,15E-22 | |
| GO.0001816 | toll-like receptor signaling pathway | 9 | 1,20E-04 | - | - | |
| GO.0016192 | vesicle-mediated transport | 140 | 1,33E-62 | 102 | 1,60E-49 | |
| GO.0070372 | wound healing | 45 | 3,69E-20 | 41 | 2,78E-23 | sky blue |