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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Thorax. 2019 Sep 26;74(12):1131–1139. doi: 10.1136/thoraxjnl-2018-212430

Table 4.

Subject Characteristics Based on Quantitative Fibrosis Score.

Fibrosis score negative (n=292) Fibrosis score positive (n=110) Unadjusted p-value* Adjusted, p-value
Age, mean (SD), years 54.8 (7.7) 64.1 (10.6) 2.97×10−14 <2.0×10−16
Male, n (%) 104 (36%) 49 (45%) 0.10 0.26
Ever smoker, n (%) 79 (27%) 40 (37%) 0.05 0.16
MUC5B Promoter Variant (rs35705950), MAF (% subjects with variant)** 0.21(38%) 0.27 (51%) 0.006 0.017

Clinical characteristics and genotype breakdown of subjects with quantitative HRCT analyses. The cutoff of 0.60 for the logarithm of fibrosis score is based on analyses presented in the text.

*

Unadjusted p-value compares characteristic between groups refer to t-tests (age) and Pearson’s chi-square test (proportions). Adjusted p-values refer to p-rvalues derived from regression of fibrosis score on age, male sex, smoking history, and MUC5B promoter variant.

**

In the reported model, rs35705950 coded as a dominant allele given small number of TT subjects. (MAF = minor allele frequency)