Table 1.
MIC and MBC Values of CSA-13, CSA-44, CSA-131, and Antibiotics/Chemotherapeutics Tested Against Escherichia coli BAA 2471, Enterobacter cloacae BAA 2468, Klebsiella pneumoniae subsp. pneumoniae BAA 2472, and Klebsiella pneumoniae BAA 2473
| CSAs, Antibiotics, Chemotherapeutics/Microorganisms | E. coli BAA 2471 MIC/MBC (µg/mL) | E. cloacaeBAA 2468 MIC/MBC (µg/mL) | K. pneumoniae subsp. pneumoniae BAA 2472 MIC/MBC (µg/mL) | K. pneumoniae BAA 2473 MIC/MBC (µg/mL) |
|---|---|---|---|---|
| CSA-13 | 1/1 | 2/2 | 2/2 | 2/4 |
| CSA-44 | 1/1 | 1/2 | 2/4 | 2/2 |
| CSA-131 | 1/1 | 1/1 | 2/2 | 2/4 |
| Ertapenem | 64/64 | 128/128 | 128/128 | >256 |
| Imipenem | 16/16 | 32/32 | 2 | >256 |
| Meropenem | 64/64 | 64/64 | 128/128 | 32/128 |
| Colistin | 0.5/0.5 | 1/4 | 1/4 | 0.5/2 |
| Gentamicin | >256 | >256 | >256 | >256 |
| Tobramycin | 32/128 | >256 | >256 | 32/256 |
| Ciprofloxacin | 128/256 | 64/256 | 64/256 | >256 |
| Fosfomycin | 8 | >256 | >256 | >256 |
| Tigecycline | 0.5/0.5 | - | - | - |
Abbreviations: CSAs, ceragenins; MIC, minimal inhibitory concentration; MBC, minimal bactericidal concentration.