Table 2.

PTP1B residues in complex with TCS401; specific intermediate exchange group

kex (s−1)	pB (%)	Residues
550 ± 40	7.8 ± 0.6	Val49 (Cγ1), Val107 (Cγ1), Val113 (Cγ1 and Cγ2), Leu119 (Cδ1), Val184 (Cγ1), Ile261, Ile281
780 ± 50	2.1 ± 0.1	Leu83 (Cδ1), Leu110 (Cδ1 and Cδ2), Val155 (Cγ1), Leu171 (Cδ1), Leu195 (Cδ1 and Cδ2), Leu204 (Cδ1), Val211 (Cγ1), Val213 (Cγ1), Leu227 (Cδ1 and Cδ2), Leu250 (Cδ1 and Cδ2), Leu260 (Cδ1), Leu272 (Cδ1), Val287 (Cγ1)
2100 ± 240	0.40 ± 0.03	Leu140 (Cδ1 and Cδ2), Leu142 (Cδ1 and Cδ2), Leu160 (Cδ1)