Figure 8.

A model depicting the regulation of FAAP20 stability by acetylation signaling. Top panel: cellular FAAP20 levels were determined by the competitive modification of Lys-152, which undergoes either ubiquitination by the SCF^FBW7 ubiquitin E3 ligase to promote degradation, or acetylation by the p300/CBP acetyltransferase to antagonize degradation. Bottom panel: disruption of FAAP20 acetylation either by the depletion of p300/CBP or by the overexpression of HDAC3 renders the lysine residue of FAAP20 susceptible to polyubiquitination, leading to FAAP20 degradation and defective FANCD2 activation.