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. 2020 Jul 16;9:e45530. doi: 10.7554/eLife.45530

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© 2020, Heger et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 3. — (A) Graphic representation of a eukaryotic cell with its typical organelles. Numbers in parentheses denote the number of bilaterian-specific orthogroups associated predominantly with a given cellular structure. Graphic drawn after the subcellular location section at uniprot.org. (B) Upper chart: Subcellular location of 157 bilaterian-specific genes. Location data is based on the corresponding human orthologues and colour-matched with the graphics in A. Lower chart: Number and name of transcription factor-associated domains present in the set of 157 bilaterian-specific genes. The 40 orthogroups are a subset of 51 orthogroups associated with the nuclear compartment. In most cases, domains names follow Pfam standards (http://pfam.xfam.org/). (C) Distribution of 84 domains found in 51 orthogroups associated with the nucleus. (D) Distribution of 77 domains found in 49 orthogroups associated with the plasma membrane. (E) Distribution of 39 domains found in 28 orthogroups associated with the cytoplasm. "Other" represents domains found only once in the respective category.