Figure 9.

A simplified four ODE model for circadian oscillations. (a) Equations of the four ODE model including activation of CCEs (equations 1–3) and four ODEs describing the rate of change in protein concentration. Time series are normalized to their means. (b) Limit cycle oscillations obtained by numerical integration of the equations shown in (a) for the following parameter values: V_R = 44.4 h⁻¹, k_Rr = 80.1, V_B = 0.142 h⁻¹, V_D2 = 19.0 h⁻¹, γ_rev = 0.241 h⁻¹, γ_db = 0.156 h⁻¹ and γ_bp = 2.58 h⁻¹.