Table 2.

TAK1 affinity of current TAK1 inhibitors.

name	IC50 [nM]	PDB crystal structure	binding mode	reference
5Z-7-Oxozeaenol	9	4GS6	covalent	[60]
hypothemycin	100	n.a.	covalent	[61]
epoxyquinol	20000	n.a.	covalent	[62]
AZ-TAK1	8	unpublished	Type I	[63]
ABC-FP	28	4L53	Type I	[64,65]
PF-04358168	1640	2YIY	Type II	[66]
PF-05381941	156	N/A	Type II	[66]
NG-25	4	4O91	Type II	[67]
LYTAK1	N/A	n.a.	N/A	[68]
takinib	9.5	5V5N	Type 1.5	[13]