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. 2020 Sep 30;10(9):200194. doi: 10.1098/rsob.200194

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — Mouse digit tip regeneration is a multi-stage process. Amputation of the distal third of the mammalian digit tip (indicated by the red hatched line in the left lower panel) results in a multi-stage regenerative process that includes epidermal closure and wound healing (second lower panel), blastema formation (third lower panel) and differentiation to form the regenerated digit tip (fourth lower panel). The known tissue sources that provide cells for the mammalian digit tip blastema, mesenchymal cells from the nerve (shown in red) and cells from the bone are shown in the top panel.