Table 1.

Functions of m⁶A writers and erasers.

	molecule	effect on m6A modification	other functions	references
m6A writers	METTL3	catalytic core of methyltransferase	enhances translation	[34,58,59]
	METTL14	stabilize METTL3/14 complex and promote the binding to RNA		[35,36]
	WTAP	promote the localization of METTL3/14 complex		[45]
	KIAA149(VIRMA)	interactions with WTAP and installation of m6A to the 3′ UTR		[48]
	RBM15/15B	binding to U-rich regions to recruit the methyltransferase complex		[25]
	METTL16	promote methylation of U6 snRNA, ncRNAs and pre-mRNAs	facilitate splicing of specific mRNA	[49–52]
	HAKAI	necessary for the m6A methylation in Arabidopsis		[53,54]
	ZC3H13	promote the WTAP localization and m6A deposition		[55,56]
	ZCCHC4	methylate human 28S rRNA		[57]
m6A erasers	FTO	remove m6A and m6Am	regulate pre-mRNA alternative splicing	[8,60,61]
	ALKBH5	remove m6A	regulate mRNA processing, metabolism and export	[62–64]