Table 3.

Parameter estimates of the population PK model

PK parameter	Value	SE	CV	95% CI
CL, dL/h	1.63	0.159	9.75	1.32–1.95
V1, dL	39.4	1.26	3.20	36.9–41.9
Q rurioctocog alfa pegol, dL/h	3.00	0.726	24.2	1.58–4.43
V2 rurioctocog alfa pegol, dL	5.32	0.817	15.4	3.72–6.92
Relative increase in CL for rurioctocog alfa pegol	1.21	0.0396	3.27	1.13–1.29
Interindividual variability in CL, %CV	41.2	0.0615	36.3	0.0491–0.290
Interindividual variability in V1, %CV	13.0	0.00574	34.1	0.00558–0.0281
Interindividual variability in relative increase in CL for rurioctocog alfa pegol versus damoctocog alfa pegol, %CV	11.5	0.00429	32.4	0.00484–0.0217
Interindividual variability for Q rurioctocog alfa pegol, %CV	15.0 (fix)	–	–	–
Interindividual variability for V2 rurioctocog alfa pegol, %CV	15.0 (fix)	–	–	–
Residual error (additive)	0.25 (fix)	–	–	–
Residual error (proportional)	0.117	0.00499	4.26	0.107–0.127

CI, confidence interval; CL, clearance; CV, coefficient of variation; LBW, lean body weight; PK, pharmacokinetic; Q, intercompartmental clearance; SE, standard error; V, volume