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. 2020 Sep 26;99(11):2611–2617. doi: 10.1007/s00277-020-04251-8

Table 2.

Clinical and genetic characteristics of acute leukemia with EP300-ZNF384 fusion (continuation of Table 1)

Case Fusion Breakpoint Treatment Chemotherapy regimen CR Current status Follow-up from determination of EP300-ZNF384 fusion (months) Follow-up from diagnosis (months)
1 EP300-ZNF384 Ex6-Ex3 Chemotherapy, Allo-HSCT VDCLP Yes Alive 26 84
2 EP300-ZNF384 Ex6-Ex3 Chemotherapy VDCLP Yes Alive 30 30
3 EP300-ZNF384 Ex6-Ex3 Chemotherapy, Allo-HSCT VDCLP Yes Alive 24 24
4 EP300-ZNF384 Ex6-Ex3, Ex6-Ex2 Chemotherapy VDCLP-like Yes Alive 19 19
5 EP300-ZNF384 Ex6-Ex3 Chemotherapy MAVP No Died 1 1
6 EP300-ZNF384 Ex6-Ex3, Ex6-Ex2 Chemotherapy VDCLP Yes Alive 20 20
7 EP300-ZNF384 Ex6-Ex3 Chemotherapy, CarT, Allo-HSCT VDCLP No Died 21 21
8 EP300-ZNF384 Ex6-Ex2 Chemotherapy, CarT, B-ALLo-HSCT VACLP No Died 35 83
9 EP300-ZNF384 Ex6-Ex3 Chemotherapy, Allo-HSCT VDCLP Yes Alive 36 36
10 EP300-ZNF384 Ex6-Ex3 Chemotherapy, Allo-HSCT VDCLP Yes Alive 46 46

CR, complete remission; Ex, exon; Allo-HSCT, allogeneic hematopoietic stem cell transplantation; CarT, chimeric antigen receptor (CAR) T cell therapy; VDCLP, vincristine, daunorubicin, cyclophosphamide, L-asparaginase, and prednisone; MAVP, mitoxantrone, cytarabine, vincristine, and prednisone; VACLP, vincristine, cytarabine, cyclophosphamide, L-asparaginase, and prednisone