Table 2.
Clinical and genetic characteristics of acute leukemia with EP300-ZNF384 fusion (continuation of Table 1)
| Case | Fusion | Breakpoint | Treatment | Chemotherapy regimen | CR | Current status | Follow-up from determination of EP300-ZNF384 fusion (months) | Follow-up from diagnosis (months) |
|---|---|---|---|---|---|---|---|---|
| 1 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy, Allo-HSCT | VDCLP | Yes | Alive | 26 | 84 |
| 2 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy | VDCLP | Yes | Alive | 30 | 30 |
| 3 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy, Allo-HSCT | VDCLP | Yes | Alive | 24 | 24 |
| 4 | EP300-ZNF384 | Ex6-Ex3, Ex6-Ex2 | Chemotherapy | VDCLP-like | Yes | Alive | 19 | 19 |
| 5 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy | MAVP | No | Died | 1 | 1 |
| 6 | EP300-ZNF384 | Ex6-Ex3, Ex6-Ex2 | Chemotherapy | VDCLP | Yes | Alive | 20 | 20 |
| 7 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy, CarT, Allo-HSCT | VDCLP | No | Died | 21 | 21 |
| 8 | EP300-ZNF384 | Ex6-Ex2 | Chemotherapy, CarT, B-ALLo-HSCT | VACLP | No | Died | 35 | 83 |
| 9 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy, Allo-HSCT | VDCLP | Yes | Alive | 36 | 36 |
| 10 | EP300-ZNF384 | Ex6-Ex3 | Chemotherapy, Allo-HSCT | VDCLP | Yes | Alive | 46 | 46 |
CR, complete remission; Ex, exon; Allo-HSCT, allogeneic hematopoietic stem cell transplantation; CarT, chimeric antigen receptor (CAR) T cell therapy; VDCLP, vincristine, daunorubicin, cyclophosphamide, L-asparaginase, and prednisone; MAVP, mitoxantrone, cytarabine, vincristine, and prednisone; VACLP, vincristine, cytarabine, cyclophosphamide, L-asparaginase, and prednisone