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. 2020 Oct 5;11:4995. doi: 10.1038/s41467-020-18819-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Whole exome sequencing identifies three major genomic subtypes of endometrioid ovarian carcinoma based on TP53 and CTNNB1 mutation status. Molecular signatures for each tumour are plotted as the fraction of transversions and transitions. Mutations are displayed as an oncoplot. Grey denotes no mutation. Upper plot shows the six most frequently mutated genes; lower plot shows select genes of interest. b Lollipop plots of five common gene targets of mutation. c Mismatch repair (MMR) mutations across cases. d Relationship between tumour mutational burden (TMB) and mutations in POLE and/or MMR genes. Ti transition, tv transversion, MSI microsatellite instability, RD residual disease.