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. 2020 Oct 5;10:16467. doi: 10.1038/s41598-020-72362-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design. EEG/EMG implantation took place at day-10, mice were then allowed 9–10 days of recovery including a 48 h period of habituation to the recording setup. This was followed by a 24 h baseline EEG/EMG recording. EEG/EMG signals were continuously recorded for the next 3 days (EEG day 1–3). Each morning at 6 a.m. on day 1–3 the Morris water maze (MWM) was performed. These 3 days are summarized as the learning period. Mice were perfused for histological analysis afterwards.