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. 2020 Oct 5;10:16467. doi: 10.1038/s41598-020-72362-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MWM performance. WT red, Cyclin D2^−/− blue. (A) Mean route efficiency in % (100% = direct swimming path) for each day (6 trials per day) in both groups. (B) Discrimination and ranking of different search strategies. Hippocampus-independent strategies were ranked with 0 points and only hippocampus-dependent strategies (direct search, focal search, and direct swimming) were ranked with 1, 2 or 3 points. (C) Proportional appearance in % of different search strategies over all trials during the 3 days of learning the MWM task in both groups. (D) Mean strategy ranking for each day (6 trials per day) in both groups. (n = 10 for each group, 6 trails per day; one-way repeated-measure ANOVA with post-hoc Bonferroni-adjusted two-sided t-test as appropriate; *: p < 0.05; **: p < 0.01; ***: p < 0.001; data presented as mean ± 1 SEM).