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. 2020 Oct 5;11:4983. doi: 10.1038/s41467-020-18769-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Mass-normalized TMRE trace for control (blue) and 1 µM oligomycin-treated (brown) L1210 cell around cell division. Both control and oligomycin-treated cells proceed through mitosis, but display distinct TMRE dynamics. b Quantifications of the TMRE increase in mitosis following mitotic arrest with STLC in control and 1 µM oligomycin-treated L1210 cells. Baseline refers to G2 TMRE levels. c Quantifications of mitotic entry in control (0.1% v/v DMSO-treated) and 1 µM oligomycin-treated L1210 cells. Cells were synchronized to G2, released and collected for cell cycle analysis at indicated timepoints. Treatments were started 15 min before releasing from G2 arrest. Each dot represents a separate culture (n = 3). d Quantifications of mitotic exit (appearance of G1 cells) for samples shown in (c). e Quantification of mass accumulation (growth) rate in individual control and 1 µM oligomycin-treated cells. Each dot represents the growth rate of a single-cell. Quantifications of the growth rates after 1 h drug exposure are shown on the right. In (b, e), boxplots depict the mean (small square), median (horizontal bar), interquartile range (IQR) (box), and 1.5× IQR (whiskers). Unpaired, two-tailed Student’s t test was used for statistical analysis.