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. 2020 Oct 5;10:16504. doi: 10.1038/s41598-020-73700-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a–g) Bubble plots of the top 20 most significant survival-related AS events in seven AS subtypes. AS subtypes of AA, AD, AP, AT, ES, RI, and ME, respectively. AS events are considered protective when Z < 0, and the opposite when Z > 0. The size and colour of the bubble show the significance of each AS event. (h–o) Kaplan–Meier survival curve of prognostic related AS events in IBC. h–o represents the survival curve of total AS and AA, AD, AP, AT, ES, RI and ME subtypes events, respectively. (p–q) independent prognosis analysis. (p) univariate independent prognosis analysis. (q) multivariate independent prognosis analysis. The red square represents HR > 1, and the green square represents HR < 1. AA: alternate acceptor; AD alternate donor; AP alternate promoter; AT alternate terminator; ES exon skip; ME mutually exclusive exons; RI: retained intron.