TABLE 5.

Gamithromycin doses required to reach stasis, 1 log₁₀ kill, 2 log₁₀ kill, and 3 log₁₀ kill of Pasteurella multocida isolates in the lungs of mice for gamithromycin monotherapy and double therapy with colistin at doses of 2.5 and 5 mg/kg twice a day (n = 4).

Strain	Monotherapy (mg/kg)		Double therapy (mg/kg)
	Gamithromycin		2.5 mg/kg colistin plus gamithromycin			5 mg/kg colistin plus gamithromycin
	Stasis	1-log10 kill	Stasis*	1-log10 kill**	2-log10 kill	Stasis**	1-log10 kill**	2-log10 kill	3-log10 kill
D18	17.99	65.32	2.64	4.83	13.55	0.76	1.56	2.90	5.66
T5	21.73	73.80	2.94	5.82	21.88	0.99	2.08	3.96	11.60
WJ11	15.58	62.19	2.78	5.37	15.27	0.99	1.93	3.73	6.87
Mean ± SD	18.43 ± 3.10	67.11 ± 6.01	2.79 ± 0.15	5.35 ± 0.51	16.90 ± 4.40	0.92 ± 0.13	1.84 ± 0.26	3.67 ± 0.54	7.46 ± 1.81

*P < 0.05 for gamithromycin doses required to reach the same antimicrobial effect with double therapy versus gamithromycin monotherapy. **P < 0.01 for gamithromycin doses required to reach the same antimicrobial effect with double -therapy versus gamithromycin monotherapy.