TABLE 4.
Differentially abundant proteins involved in lipid metabolism in MTBC lineages.
| Protein name | Gene symbol | Rv number | Less abundance (lineage/s) | Increased abundance lineage/s) |
| Fatty acid synthase Fas | fas | Rv2524c | 7 | 3, 4, 5 |
| Long-chain-fatty-acid–CoA ligase FadD15 | fasD15 | Rv2187 | 7 | 3, 4, 5 |
| Probable enoyl-CoA hydratase EchA11 | EchA11 | Rv1141c | 7 | 3, 4, 5 |
| (3R)-Hydroxyacyl-ACP dehydratase subunit HadB | hadB | Rv0636 | 7 | 3, 4, 5 |
| Polyketide synthase Pks13 | pks13 | Rv3800c | 7 | 3, 4, 5 |
| Methoxy mycolic acid synthase MmaA3 | mmaA3 | Rv0643c | 7 | 3, 4, 5 |
| 3-Oxoacyl-[acyl-carrier-protein] synthase 1 KasA | kasA | Rv2245 | 7 | 3, 4, 5 |
| 3-Oxoacyl-[acyl-carrier-protein] synthase 2 | ksaB | Rv2246 | 7 | 3, 4, 5 |
| Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (Alpha subunit) AccA2 | accA2 | Rv0973c | 4, 7 | 3, 5 |
| Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD2 | accD2 | Rv0974c | 4, 7 | 3, 5 |
| Propionyl-CoA carboxylase beta chain 6 AccD6 | accD6 | Rv2247 | 4, 7 | 3, 5 |
| Malonyl CoA-acyl carrier protein transacylase | fadD | Rv0166 | 5, 7 | 3, 4 |
| Long-chain-fatty-acid–AMP ligase FadD32 | fadD32 | fadD32 | 5, 7 | 3, 4 |
| Galactofuranosyltransferase GlfT2 | GlfT2 | Rv3808c | 5, 7 | 3, 4 |
| Phthiocerol synthesis polyketide synthase type I PpsA | ppsA | Rv2931 | 4, 7 | 3,5 |
| Phthiocerol synthesis polyketide synthase type I PpsB | ppsB | Rv2932 | 4, 7 | 3, 5 |
| Phenolpthiocerol synthesis type-I polyketide synthase PpsC | ppsC | Rv2933 | 4, 7 | 3, 5 |
| Doxorubicin resistance ATP-binding protein DrrA | drrA | Rv2936 | 4, 7 | 3, 5 |
| Phthiocerol synthesis polyketide synthase type I PpsD | ppsD | Rv2934 | 4, 7 | 3, 5 |
| Phthiocerol synthesis polyketide synthase type I PpsE | ppsE | Rv2935 | 4, 7 | 3, 5 |
| Steroid 3-ketoacyl-CoA thiolase | fadA5 | Rv3546 | 4, 7 | 3, 5 |
| Polyketide synthase Pks7 | Pks7 | Rv1661 | 4, 7 | 3, 5 |
| Long-chain-fatty-acid–AMP ligase FadD26 | fadD26 | Rv2930 | 4, 7 | 3, 5 |
| Polyketide synthase-like Pks10 | Pks10 | Rv1660 | 5, 7 | 3, 4 |
| Phthioceranic/hydroxyphthioceranic acid synthase | Pks2 | Rv3825c | 5, 7 | 3, 4 |
| Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase | Rv2952 | Rv2952 | 7 | 3,4, 5 |
| Putative phthiocerol dimycocerosate transporter LppX | lppx | Rv2945c | 3,7 | 4, 5 |
| Mycocerosic acid synthase-like polyketide synthase | pks5 | Rv1527c | 7 | 3, 4 |
| Arabinofuranosyltransferase AftB | aftb | Rv3805c | 3, 4, 7 | 5 |
| Putative diacyglycerol O-acyltransferase Rv2285 | Rv2285 | Rv2285 | 7 | 3, 4, 5 |
| Peptidoglycan endopeptidase RipA | ripA | Rv1477 | 4 | 3, 7 |
| Peptidoglycan endopeptidase RipB | ripB | Rv1478 | 7 | 3, 4, 5 |
| Probable penicillin-binding protein DacB1 | dacB1 | Rv3330 | 7 | 3, 4, 5 |
| Phosphoglucosamine mutase | glmM | Rv3441c | 7 | 3, 4, 5 |
| Rhamnosyl O-methyltransferase | Rv2959c | Rv2959c | 3, 7 | 4, 5 |
| Uncharacterized glycosyl hydrolase Rv2006 | Rv2006 | Rv2006 | 4, 7 | 3, 5 |
| Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks1 | pks1 | Rv2946c | 3, 4, 7 | 5 |
| Steroid C26-monooxygenase | cyp125 | Rv3545c | 3,4, 7 | 5 |
| Long-chain-fatty-acid–AMP ligase FadD30 | fadD30 | Rv0404 | 3, 4, 7 | 5 |
| Acyl-CoA dehydrogenase FadE28 | fadE28 | Rv3544c | 3, 4, 7 | 5 |
| Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH | fadh | Rv1175c | 5, 7 | 3, 4 |
| UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase | murF | Rv2157c | 3, 5, 7 | 4 |
| UDP-N-acetylmuramoylalanine–D-glutamate ligase | murD | Rv2155c | 5, 7 | 3, 4 |
| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase | murE | Rv2158c | 3, 5, 7 | 4 |
| Isoniazid-induced protein IniC | iniC | Rv0343 | 5, 7 | 3, 4 |
| Isoniazid-induced protein IniA | iniA | Rv0342 | 5, 7 | 3, 4 |