TABLE 5.

Differentially abundant proteins involved in energy metabolism in MTBC lineages.

Protein name	Gene symbol	Rv number	Less abundance (lineage/s)	Increased abundance lineage/s)
Glucose-6-phosphate isomerase Pgi	pgI	Rv 0946c	3, 4, 5	7
6-Phosphofructokinase PfkA	pfkA	Rv3010c	3, 4, 5	7
Probable alcohol dehydrogenase AdhA	adhA	Rv1862	3, 4, 5	7
Possible L-lactate dehydrogenase (cytochrome) LldD1	LldD1	Rv0694	3, 4, 5	7
Putative citrate synthase II CitA	citA	Rv0889c	7	3, 4, 5
Isocitrate lyase Icl	Icl1	Rv0467	4, 7	3, 5
6-Phosphogluconate dehydrogenase Gnd1	gnD1	Rv1844c	5, 7	5, 7
6-Phosphogluconate dehydrogenase, decarboxylating Gnd2	gnD2	Rv1122	5, 7	5, 7
Glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	Zwf2	Rv1447c	3, 4, 5	7
Fumarate reductase flavoprotein subunit	frdA	Rv1552	3, 5	4, 7
Fumarate reductase iron-sulfur subunit	frdB	Rv1553	3, 5	4, 7
Putative succinate-semialdehyde dehydrogenase 2	gabD2	Rv1731	3, 5	4, 7
Citrate synthase 1	gltA2	Rv0896	5	3, 4, 7
Succinate dehydrogenase 2 membrane subunit SdhC	sdhC	Rv3316	5	3, 4, 7
Succinate dehydrogenase flavoprotein subunit	sdhA	Rv3318	5	3, 4, 7
Probable succinate dehydrogenase SdhB	sdhB	sdhB	5	3, 4, 7
2-Methylcitrate synthase	prpC	Rv1131	3, 4, 5	7
2-Methylcitrate dehydratase	prpD	Rv1130	3, 4, 5	7
Probable NADH dehydrogenase Ndh	ndH	Rv1854C	4, 7	3, 5
NADH dehydrogenase-like protein Rv1812c	nadH	Rv1812c	7	3, 4, 5
Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH	fadH	RV1812c	5, 7	3, 4
Quinolinate synthase A	nadA	Rv1594	7	3, 4, 5
L-Aspartate oxidase	nadB	Rv1595	7	3, 4, 5
Nicotinate-nucleotide pyrophosphorylase	nadC	Rv1596	7	3, 4, 5
Isocitrate lyase 2	aceaB	Rv1916	4	3, 5, 7
Putative isocitrate lyase subunit A	aceaA	Rv1915	4	3, 5, 7