Table 2.
Univariate and Multivariate Binary Logistic Regression Analysis
| Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|
| p Value | Exp (B) | p Value | Exp (B) | 95% CI for Exp (B) | |
| Age (per yr increase) | 0.08 | 1.10 | 0.38 | 1.09 | 0.90–1.30 |
| ECVCT (per % increase) | <0.001 | 1.49 | 0.001 | 1.60 | 1.21–2.10 |
| AVA (per cm2 increase) | 0.92 | 1.12 | – | ||
| AV mean gradient (per mm Hg decrease) | 0.36 | 0.98 | – | ||
| AV Vmax (per m/s decrease) | 0.55 | 0.77 | – | ||
| AV calcium score (per HU increase) | 0.56 | 1.00 | – | ||
| E/A ratio (per U increase) | 0.04 | 1.74 | – | ||
| Male | 0.26 | 1.86 | 0.81 | 0.81 | 0.14–4.60 |
| GLS (per % decrease) | 0.61 | 0.98 | – | ||
| hs-TnT (per ng/l increase) | 0.06 | 1.01 | – | ||
| Indexed LV mass on echo (per g/m2 increase) | 0.02 | 1.02 | – | ||
| Indexed SV (per ml/m2 decrease) | 0.28 | 0.97 | – | ||
| IVSd (per cm increase) | 0.005 | 44.66 | – | ||
| LA diameter (per cm increase) | 0.08 | 2.04 | – | ||
| Lateral E/E′ (per U increase) | 0.11 | 1.04 | – | ||
| LBBB | 0.60 | 1.56 | – | ||
| LVEF (per % increase) | 0.18 | 1.04 | – | ||
| MCF (per % decrease) | 0.02 | 0.91 | – | ||
| Mitral annulus S′ (per m/s decrease) | 0.08 | 0.00 | – | ||
| MV Dec time (per ms increase) | 0.87 | 1.00 | – | ||
| NT-proBNP (per ng/l increase) | 0.41 | 1.00 | – | ||
| PWd (per cm increase) | 0.003 | 53.83 | 0.46 | 4.04 | 0.10–162.36 |
| RBBB | 0.001 | 9.22 | 0.01 | 16.84 | 1.87–148.54 |
| RWT (per cm increase) | 0.006 | 178.47 | – | ||
| S-L criteria (per mV decrease) | 0.06 | 0.26 | – | ||
| TAPSE (per cm decrease) | 0.81 | 0.87 | – | ||
| V/M ratio (per mV/g/m2 decrease) | 0.02 | 0.00 | – | ||
ECVCT and the presence of RBBB were associated with AS-Amyloid on univariate and multivariate analysis. For every 1% increase in extracellular volume quantification by computed tomography imaging (ECVCT), there was a 1.6-fold increased likelihood of AS-amyloid. The V/M ratio was not included in the multivariate analysis because this would have excluded nearly one-third of patients (32 in total) due to bundle branch block or ventricular paced rhythm. Only 1 parameter representing LV wall thickness or mass was included in the multivariate analysis to avoid multicollinearity (in this case, PWd, as it had the strongest association on univariate analysis).
Exp (B) = exponentiation of the B coefficient; GLS = global longitudinal strain; MV = mitral valve; RWT = relative wall thickness; other abbreviations as in Table 1.