Table 3.
Clinical features and prognoses of 12 neonates with congenital TTP.
| Case number | Sex | Time of onset | Jaundice | Hematuria | Anemia | Thrombocytopenia | Fever | Seizure | Abnormal renal function | ADAMTS13 activity | Family history | Outcome | References |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | Girl | 40 h after birth | + | + | + | + | + | – | + | <1% | + | Deceased | (5) |
| Case 2 | Boy | 1 day after birth | + | + | + | + | – | – | – | 5% | – | Survived | (6) |
| Case 3 | Boy | 3 days after birth | + | – | + | + | + | – | – | 4% | + | Survived | (6) |
| Case 4 | Girl | 6 h after birth | + | + | + | + | – | + | – | 10% | – | Survived | (7) |
| Case 5 | Boy | 11 h after birth | + | – | + | + | – | – | – | <0.5 | – | Survived | (8) |
| Case 6 | Girl | 1 day after birth | + | – | – | + | – | – | + | 0.5% | – | Survived | (8) |
| Case 7 | Boy | 4 h after birth | + | + | + | + | – | – | + | 5% | – | Survived | (9) |
| Case 8 | Boy | 6 h after birth | + | – | + | + | – | – | + | <5% | – | Survived | (10) |
| Case 9 | Girl | 4 h after birth | + | + | + | + | – | – | + | 10% | + | Survived | (11) |
| Case 10 | Girl | 1 day after birth | + | – | + | + | – | – | – | 0.5% | – | Survived | (12) |
| Case 11 | Boy | Not specified | + | – | + | + | – | – | – | – | – | Deceased | (13) |
| Case 12 | Boy | 27 days after birth | + | – | + | + | – | + | + | <10& | – | Deceased | (14) |