Table 2.
Interacting amino acids in TS found after docking of 5-FU PRAs.
| fdUMP | PRA1 | PRA2 | PRA3 | PRA4 | PRA5 | PRA6 | PRA7 | PRA8 | PRA9 | PRA10 | PRA11 | PRA12 | PRA13 | PRA14 | PRA15 | PRA16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ARG50 | ARG175 | ARG50 | ARG50 | ARG50 | ARG50 | ARG50 | ARG175 | ARG175 | ARG176 | ARG175 | ARG215 | ARG50 | ALA312 | ARG175 | HIS256 | ARG175 |
| ARG175 | ARG176 | ARG175 | ARG175 | ARG175 | ARG175 | ARG175 | ARG176 | ARG176 | ARG215 | ARG176 | ARG50 | ARG175 | ARG175 | ARG176 | ARG175 | ARG176 |
| ARG176 | ARG215 | ARG176 | ARG176 | ARG176 | ARG176 | ARG215 | ARG215 | ARG215 | ARG50 | ARG215 | ASN226 | ARG176 | ARG176 | ARG215 | ARG176 | ARG215 |
| ARG215 | ARG50 | ARG215 | ARG215 | ARG215 | ARG215 | ASN226 | ASN226 | ARG50 | ASN226 | ASN226 | ASP218 | ARG215 | ARG215 | ARG50 | ARG215 | ARG50 |
| ASN226 | ASN226 | ASN226 | ASN226 | ASN226 | ASN226 | ASP218 | CYS195 | ASN226 | CYS195 | ASP218 | CYS195 | ASN226 | ARG50 | ASN226 | ARG50 | ASN226 |
| CYS195 | CYS195 | CYS195 | CYS195 | ASP218 | CYS195 | CYS195 | GLN214 | CYS195 | HIS196 | GLN214 | GLY222 | ASP218 | ASP218 | ASP218 | ASN226 | ASP218 |
| HIS196 | LEU192 | MET311 | MET311 | CYS195 | GLN214 | HIS196 | HIS196 | HIS196 | ILE108 | HIS256 | SER216 | GLN214 | MET311 | CYS195 | CYS195 | GLY222 |
| SER216 | SER216 | SER216 | TRP109 | SER216 | HIS196 | LEU192 | HIS256 | ILE108 | PHE225 | SER216 | TYR258 | MET311 | SER216 | SER216 | GLN214 | HIS256 |
| TYR258 | TRP109 | TRP109 | TYR258 | SER216 | SER216 | SER216 | SER216 | SER216 | TYR258 | TYR258 | TYR258 | TYR258 | HIS196 | SER216 | ||
| TYR258 | TYR258 | TRP109 | TYR258 | TRP109 | TRP109 | SER216 | ||||||||||
| TYR135 | TYR258 | TYR258 | TYR258 | |||||||||||||
| TYR258 |