Table 1.

One-pot, multi-component synthesis of bis-heterocycles 4a-j.

Entry	Aminouracila	CH-acida	Product	Time (min)	Yield (%)
1	6-Aminothiouracil	2-Hydroxy-1,4-naphthoquinone	4a	5	76
2	6-Aminouracil	4-Hydroxycoumarin	4b	5	68
3	6-Amino-1,3-dimethyluracil	4-Hydroxycoumarin	4c	5	73
4	6-Aminothiouracil	Dimedone	4d	10	79
5	6-Amino-1,3-dimethyluracil	Dimedone	4e	10	85
6	6-Aminouracil	Dimedone	4f	30	65
7	6-Aminouracil	Thiobarbituric acid	4g	5	90
8	6-Aminouracil	Barbituric acid	4h	20	70
9	6-Amino-1,3-dimethyluracil	Barbituric acid	4i	20	72
10	6-Amino-1,3-dimethyluracil	2-Hydroxy-1,4-naphthoquinone	4j	10	69

^aVarious 6-aminouracils (2 mmol), terephthalaldehyde (1 mmol), and CH-acids (2 mmol) were used in EtOH at reflux, without any catalyst.