Figure 1.

Discriminant biomolecules selected by sequential and orthogonalized covariance selection coupled with linear discriminant analysis (SO-CovSel–LDA). Candidate biomarkers are presented according to the order in which they respective data matrices were entered into the model: (A) amino acids and derivatives, (B) inflammatory biomolecules, and (C) mitochondrial-derived vesicle cargo molecules. IL1-ra, interleukin 1 receptor agonist; MIP-1β, macrophage inflammatory protein 1β; NDFUS3, nicotinamide adenine dinucleotide reduced form (NADH), ubiquinone oxidoreductase subunit S3.