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. 2020 Sep 22;11:2101. doi: 10.3389/fmicb.2020.02101

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Copyright © 2020 Lachén-Montes, Corrales, Fernández-Irigoyen and Santamaría.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential olfactory proteomics workflows to characterize molecular disturbances caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The combination of commercial or primary cell lines from the olfactory mucosa with the transfection of expression systems for SARS-CoV-2 proteins (or infection with viral particles) represents a valuable approach to study the impact of SARS-CoV-2 infection in this region. In addition, the proteomic analysis of the OE-OB-OT axis from patients with COVID-19 will provide novel insights into the olfactory dysfunction triggered by SARS-CoV-2. GBC, globular basal stem cell; HBC, horizontal basal stem cell; OB, olfactory bulb; OE, olfactory epithelium; OEC, olfactory ensheathing cell; OM, olfactory mucosa mesenchymal stem cell; ON, olfactory neuron; OT, olfactory tract.