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. 2020 Sep 22;8:578239. doi: 10.3389/fcell.2020.578239

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Copyright © 2020 Vitre, Guesdon and Delaval.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFT proteins function throughout the cell cycle in association with microtubules and motors. IFT proteins contribute to a variety of interphase and mitotic molecular mechanisms. IFT proteins are required for ciliogenesis and for the regulation of cytoplasmic microtubules which were both linked to ciliopathies related phenotypes. Novel non-ciliary mechanisms for IFT proteins in mitosis have been identified. Perturbation of those mechanisms may also be linked to developmental defects and diseases. MTs, microtubules; CHR, chromosome.