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. 2020 Sep 22;8:561791. doi: 10.3389/fcell.2020.561791

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Copyright © 2020 Robert, Knutson, Rechtsteiner, Garvis, Yvert, Strome and Palladino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ectopic TGF-beta signaling contributes to loss of germline identity in set-2 mutant animals. (A) sma-9, daf-5, sma-10, and sma-3 RNAi knock-down (left panel) and kin-29 and obr-3 RNAi knock-down (right panel) delay the onset of sterility of set-2 mutant animals compared to animals fed with an empty RNAi vector (no RNAi). Number of fertile plates per generation (upper panel) and number of animals per fertile plate in F6, F10, and F12 (lower panel) are shown. (B) Detection by smFISH of daf-5 (upregulated contributor) and sygl-1 (control gene) transcripts in P0 set-2/+ and F4 set-2/set-2 germlines. The distal tip of the gonad is on the left.