Table 2. KEGG pathway analysis of aberrantly methylated-differentially expressed oncogenes and TSGs in hepatocellular carcinoma.

Pathway ID	Pathway name	Gene no.	%	P value	Genes
Up-regulated and hypomethylated expression
hsa05200:	Pathways in cancer	6	9.50	3.59E-04	GNA13, EGFR, AR, GNAI2, RHOA, PIK3R1
hsa04071	Sphingolipid signaling pathway	4	6.30	9.97E-04	GNA13, GNAI2, RHOA, PIK3R1
hsa04611	Platelet activation	4	6.30	1.18E-03	GNA13, GNAI2, RHOA, PIK3R1
hsa04810	Regulation of actin cytoskeleton	4	6.30	5.07E-03	GNA13, EGFR, RHOA, PIK3R1
hsa04015	Rap1 signaling pathway	4	6.30	5.20E-03	EGFR, GNAI2, RHOA, PIK3R1
Down-regulated and hypermethylated expression
hsa04722	Neurotrophin signaling pathway	4	7.04	5.53E-03	PRDM4, BAX, FOXO3, PRKCD
hsa04210	Apoptosis	3	5.28	1.38E-02	DFFA, BAX, CASP8
hsa05200	Pathways in cancer	5	8.80	2.94E-02	BMP4, BCR, BAX, CASP8, PML