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. 2020 Oct 5;10:16495. doi: 10.1038/s41598-020-73457-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell cycle arrest in G2/M phase. (A) Cell distribution in each phase of the cell cycle for control, CAP, TMZ and CAP–TMZ variables. (B) Statistical significance in the G2/M phase for U87MG cells 6 days after treatment with 180 s of plasma, 10 and 50 μM temozolomide and CAP–TMZ combined. The drug was replaced every alternate day. The results were reproduced with a set of six samples per condition. Error bars indicate the standard error of the mean, and the asterisk indicates statistical significance compared to the untreated condition unless otherwise noted.