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. 2020 Oct 5;10:16515. doi: 10.1038/s41598-020-73257-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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NEFH upstream sequence analysis and construct design. (A) Sequence conservation between 40 placental mammal species within the 2.5 kb region directly upstream of the human NEFH transcriptional start site, i.e. the putative human NEFH promoter region. Conservation level between 0 and 1 was assigned to each nucleotide. Units of conserved regions have been defined as Blocks F, K, D, D1 and (A,B) Schematic representation of human NEFH promoter constructs driving an EGFP cDNA. Conserved regions hF and hA consisting of Block F and Block A, and the spacer are indicated. The murine Nefh promoter is also given for reference. Promoter element sizes are given in base pairs (bp).