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. 2020 Oct 5;10:16490. doi: 10.1038/s41598-020-73752-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of lungs from naïve WT and Spred2^−/− mice. (a) Lung tissues were removed from WT and Spred2^−/− mice and examined by H&E staining. Bronchi are indicated by (B). The original magnification was 200×. The scale bars are 100 μm. (b) Naïve WT and Spred2^−/− mice were intraperitoneally injected with BrdU. Two hours later, mice were euthanized and the incorporation of BrdU was examined by IHC. The number of BrdU⁺ cells in five bronchi were counted and presented as BrdU⁺ cells/100 cells. The results are presented as mean ± SEM. n = 5. The original magnification was 400×. The scale bars are 50 μm. (c) The expression of the Cadh1, Fn1, Vim and Col1a1 gene was examined by qRT-PCR. The results are presented as mean ± SD. n = 4. *p < 0.05. ***p < 0.0001.