Table 4.
Encapsulation Properties of HMI.
| HMI Type | Substances encapsulated with HMI | Encapsulation/Fabrication Method | Encapsulation Efficiency | Major Findings | References |
|---|---|---|---|---|---|
| OSA- and DDSA- derivatives of inulin. | Beta-carotene | Solvent evaporation | N/A | The DDSA (2) sample was more effective than the OSA-inulin and Inutec SP1 samples for encapsulating and releasing beta-carotene. | Kokubun et al. (2018) |
| Ac-In and Prop-In inulin. | Dexpanthenol | Spray-drying | 100 % for both | Ac-In and Prop-In inulin are more effective at encapsulating dexpanthenol than inulin is. | Walz et al., 2018a |
| AcIn inulin. | Mesalamine | Spray-drying | 109 % ± 10 % and 84 % ± 5 % | Mesalamine was encapsulated with high encapsulation efficiency along with high enzymatic degradability | Walz et al., 2018b |
| Lauryl carbamate derivative of inulin (Inutec SP1®, INT) | PTX and Doxorubicin | Thin-film hydration for INT-Micelles | 76.6 ± 11.23 % for INT-P, 89.5 ± 4.6 % for INT-D, 89.9 ± 3 % for INT-DP for DOX, and 48.6 ± 0.8 % for PTX | The efficiency of drug encapsulation is very high for INT micelles with a clathrin-mediated endocytosis pathway | Kesharwani et al. (2019) |
| OSA-inulin | Beta-carotene | Freeze-drying | N/A | Beta-carotene was solubilized within the micelles ranging from 12 −25 mg/g of OSA-inulin | Han et al. (2020) |
| Lauryl carbamate derivative of inulin (Inutec SP1®, INT) | PTX | Thin film hydration and solvent evaporation for INT-micelles | 95.66 ± 2.25 % | PTX-loaded INT micelles demonstrated outstanding drug encapsulation efficiency and drug loading with in vivo antitumor activity | Muley et al. (2016) |
| INVITE | CUR and CLX | dialysis method for INVITE micelles | 37.1 ± 1.5 for INVITE-CUR and 52.3 ± 1.3 for INVITE-CLX | Encapsulation of CUR and CLX in INVITE micelles boosted the water solubility of CUR and CLX and Encapsulation efficiency of INVITE-CLX was higher than that of INVITE-CUR | Mandracchia et al. (2016) |
| RGD-peptide conjugated inulin | EPB | Modified nanoprecipitation and dialysis for inulin-ibuprofen conjugates | 81.3 % | The RGD-conjugated EPB-loaded nanoparticles exhibit excellent encapsulation efficiency and antitumor efficacy | Zhang et al. (2016) |
OSA = octenyl succinic anhydrides, DDSA = dodecenyl succinic anhydrides, CUR = curcumin, EPB = epirubicin, CLX = celecoxib, PTX = paclitaxel.