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. 2020 Sep 22;8:561703. doi: 10.3389/fcell.2020.561703

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Copyright © 2020 Xu, Liu, Chen, Ye, Chen, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic elucidation of m6A in BCSCs. Exposure of breast cancer cells to hypoxia can induce ALKBH5-mediated demethylation of NANOG mRNA, leading to increased expression of NANOG, and increasing the percentage of BCSCs.