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Schematic elucidation of m6A in GSCs. (A) Cui et al. and Zhang et al. found that RNA m6A demethylase ALKBH5 and FTO are aberrantly expressed in GSCs, and they enhance self-renewal and tumorigenesis of GSCs through regulation of FOXM1 and ADAM19, respectively. (B) Visvanathan et al. found that METTL3 is upregulated in GSCs. METTL3-mediated methylation in SOX2 mRNA through recruitment of HuR to enhance its stability in GSCs, the increased level of the SOX2 enhanced radiation resistance.
