Figure 2.

Plots of Replication Enrichment Ratios and Respective 95% Confidence Intervals by Phenotype in CCSS

Replication enrichment ratios (RERs) left of the vertical line corresponding to RER = 1 suggest meta-GWAS hit replication depletion, i.e., observations of fewer replications of meta-GWAS hits than expected. Phenotype RERs are color coded based on similarity: anthropometric (blue) and cardiometabolic disease (red). The observed numbers of replications included in the figure are under the “GWAS” model (Table 1).