Figure 4.

Plots of Phenotype-Specific Replication Enrichment Ratios and Respective 95% Confidence Intervals in SJLIFE Samples Unexposed or Exposed to Treatments

Treatments were defined as cancer treatments associated with phenotypes. Phenotypes with any evidence of replication depletion (RER < 1) in our main analysis that showed either significant (p < 0.05) or suggestive (p < 0.2) replication depletion in SJLIFE treatment-exposed samples are included in this figure. Sample sizes by exposure strata (N_TX-, No Treatment; N_TX+, Treatment) are provided, as well as likelihood ratio test p values representing treatment associations with phenotypes (P_TX) and incremental changes in adjusted R² (ΔR_TX²) after removing treatment variables from clinical models. Phenotypes are ordered based on ΔR_TX² values, with larger ΔR_TX² values reflecting greater treatment influence on phenotype variation.